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Compounds for inhibiting bacterial growth via phosphatidylglycerol binding
Burns, Dennis H. English, Douglas S.
Burns, Dennis H.
English, Douglas S.
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U.S. 20190029998 A1
Adobe PDF, 1.14 MB
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2019-01-31
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Burns, D.H., English, D.S., inventors; Wichita State University, assignees. Compounds for inhibiting bacterial growth via phosphatidylglycerol binding. United States patent US 20190029998 A1. 2019, January 31.
Abstract
Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
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WSU inventors: Dennis H. Burns, Dept. of Chemistry, College of Liberal Arts and Sciences, Douglas S. English, Dept. of Chemistry, College of Liberal Arts and Sciences
Application No: 16/048009 filed July 27, 2018. Patent No: US 20190029998 A1 granted January 31, 2019.
Application No: 16/048009 filed July 27, 2018. Patent No: US 20190029998 A1 granted January 31, 2019.
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United States Patent and Trademark Office
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Status: Active; Anticipated expiration: 2037-01-27