Seneca Valley Virus Exploits TEM8, a collagen receptor implicated in tumor growth

Loading...
Thumbnail Image
Authors
Evans, David J.
Wasinger, Alexa M.
Brey, Robert N.
Dunleavey, James M.
St Croix, Brad
Bann, James G.
Issue Date
2018-11-06
Type
Article
Language
en_US
Keywords
Anthrax , Protective antigen , Seneca Valley Virus , Type VI collagen , Small cell lung cancer , TEM8/ANTXR1 , Neuroendocrine tumors
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract

Recent studies reveal that Seneca Valley Virus (SVV) exploits tumor endothelial marker 8 (TEM8) for cellular entry, the same surface receptor pirated by bacterial-derived anthrax toxin. This observation is particularly significant as SVV is a known oncolytic virus which selectively infects and kills tumor cells, particularly those of neuroendocrine origin. TEM8 is a transmembrane glycoprotein that is preferentially upregulated in some tumor cell and tumor-associated stromal cell populations. Both TEM8 and SVV have been evaluated for targeting of tumors of multiple origins, but the connection between the two was previously unknown. Here, we review currently understood interactions between TEM8 and SVV, anthrax protective antigen (PA), and collagen VI, a native binding partner of TEM8, with an emphasis on potential therapeutic directions moving forward.

Description
© 2018 Evans, Wasinger, Brey, Dunleavey, St. Croix and Bann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Citation
Evans DJ, Wasinger AM, Brey RN, Dunleavey JM, St. Croix B and Bann JG (2018) Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth. Front. Oncol. 8:506
Publisher
Evans DJ, Wasinger AM, Brey RN, Dunleavey JM, St. Croix B and Bann JG (2018) Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth. Front. Oncol. 8:506
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
2234-943X
EISSN