Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations

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Authors
Bhakta, Mehul N.
Hollenberg, Paul F.
Wimalasena, Kandatege
Issue Date
2005-01-14
Type
Article
Language
eng
Keywords
Research Support, N.I.H., Extramural , Research Support, U.S. Gov't, P.H.S.
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Abstract

The experimental evidence presented in this manuscript suggest against the widely accepted single electron/proton transfer mechanism for P450 catalyzed N-dealkylations and provides strong support for a hydrogen atom abstraction mechanism.

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Citation
Chemical communications (Cambridge, England). 2005 Jan 14; (2): 265-7.
Publisher
Royal Society of Chemistry
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DOI
ISSN
1359-7345
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