Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations
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Authors
Bhakta, Mehul N.
Hollenberg, Paul F.
Wimalasena, Kandatege
Advisors
Issue Date
2005-01-14
Type
Article
Keywords
Research Support, N.I.H., Extramural , Research Support, U.S. Gov't, P.H.S.
Citation
Chemical communications (Cambridge, England). 2005 Jan 14; (2): 265-7.
Abstract
The experimental evidence presented in this manuscript suggest against the widely accepted single electron/proton transfer mechanism for P450 catalyzed N-dealkylations and provides strong support for a hydrogen atom abstraction mechanism.
Table of Contents
Description
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Publisher
Royal Society of Chemistry
Journal
Book Title
Series
Chemical communications (Cambridge, England)
Chem. Commun. (Camb.)
Chem. Commun. (Camb.)
PubMed ID
DOI
ISSN
1359-7345