This study explored how computer anxiety and technology acceptance played roles in online learning interests among social work students. The study with cross-sectional and purposive sampling methods recruited 151 social work students in a Midwest school of social work program. Hierarchical multivariate regression revealed that a high level of computer anxiety was related to a low level of online learning interests. Conversely, a high level of technology acceptance (perceived usefulness) was associated with a high level of online learning interests. Social work programs may consider developing and providing appropriate technological training, reducing technological barriers, and obtaining feedback from students for their online learning experience to increase online learning interests by reducing computer anxiety and increasing technology acceptance. © 2024 Taylor & Francis Group, LLC.