Growing competition for a limited number of seats requires physician assistant (PA) programs to efficiently identify qualified applicants most likely to succeed. Personality inventories may be useful to evaluate applicants, but strong evidence of their value in the admission selection process is limited. We assessed correlations between the NEO Personality Inventory-Revised (NEO-PI-R) and pre-determined application selection criteria as well as professional, academic, and clinical performance indicators among 47 Wichita State University PA students. Statistical analysis demonstrated that neuroticism was moderately correlated with course scores <82% as well as the summative exam score. Agreeableness and conscientiousness were correlated with professional performance as measured by professional warnings and counseling.