Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G

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Issue Date
1994-01-14
Authors
Groutas, William C.
Kuang, Rongze
Venkataraman, Radhika
Advisor
Citation

Biochemical and biophysical research communications. 1994 Jan 14; 198(1): 341-9.

Abstract

A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion.

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