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Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G

Groutas, William C.
; 
Kuang, Rongze
; 
Venkataraman, Radhika
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Authors
Groutas, William C.
Kuang, Rongze
Venkataraman, Radhika
Other Names
Wichita State University. Department of Chemistry
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Time Period
Advisors
Original Date
Digitization Date
Issue Date
1994-01-14
Type
Article
Genre
Keywords
Research Support, U.S. Gov't, P.H.S.
Subjects (LCSH)
Cathepsins/blood
Cyclic S-Oxides/pharmacology
Pancreatic Elastase/blood
Thiadiazoles/pharmacology
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Journal Issue
Citation
Biochemical and biophysical research communications. 1994 Jan 14; 198(1): 341-9.
Abstract
A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion.
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Full text of this article is not available in SOAR.
Publisher
Elsevier
Journal
Book Title
Series
Biochemical and biophysical research communications
Biochem. Biophys. Res. Commun.
Digital Collection
URI
http://hdl.handle.net/10057/4299
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PubMed ID
DOI
ISSN
0006-291X
EISSN
Collections
CHEM Faculty Publications
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