Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G

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Authors
Groutas, William C.
Kuang, Rongze
Venkataraman, Radhika
Advisors
Issue Date
1994-01-14
Type
Article
Keywords
Research Support, U.S. Gov't, P.H.S.
Research Projects
Organizational Units
Journal Issue
Citation
Biochemical and biophysical research communications. 1994 Jan 14; 198(1): 341-9.
Abstract

A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion.

Table of Contents
Description
Full text of this article is not available in SOAR.
Publisher
Elsevier
Journal
Book Title
Series
Biochemical and biophysical research communications
Biochem. Biophys. Res. Commun.
URI
http://hdl.handle.net/10057/4299
PubMed ID
DOI
ISSN
0006-291X
EISSN
Collections
CHEM Faculty Publications