Compounds for inhibiting bacterial growth via phosphatidylglycerol binding

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Authors
Burns, Dennis H.
English, Douglas S.
Issue Date
2020-06-02
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Patent
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Abstract

Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.

Description
WSU inventors: Dennis H. Burns, Dept. of Chemistry, College of Liberal Arts and Sciences, Douglas S. English, Dept. of Chemistry, College of Liberal Arts and Sciences
Application No. 16/048,009 filed July 27, 2018. Patent No: U.S. 10,668,048 granted June 2, 2020
Citation
Burns, Dennis H.; English, Douglas S., inventors. Wichita State University, assignee. Compounds for inhibiting bacterial growth via phosphatidylglycerol binding. United States patent U.S. 10,668,048. 2020, June 2.
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United States Patent and Trademark Office
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Status: Active;
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