Synthesis and secretion of gonadotropins including structure-function correlates

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Authors
Bousfield, George R.
Dias, James A.
Advisors
Issue Date
2011-07-08
Type
Article
Keywords
Transcription , FSH beta , LH beta , Common alpha subunit , GnRH
Research Projects
Organizational Units
Journal Issue
Citation
Bousfield, George R., and James A. Dias. 2011. "Synthesis and secretion of gonadotropins including structure-function correlates". Reviews in Endocrine & Metabolic Disorders, 12(4), pp:289-302.
Abstract

The synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production of biologically active gonadotropin thus requires appropriately folded and glycosylated subunits that assemble to form the heterodimeric hormone. Here we overview recent literature on regulation of gonadotropin subunit gene expression and current understanding of the assembly and secretion of biologically active gonadotropic hormones. Finally, we discuss the therapeutic potential of understanding glycosylation function towards designing new forms of gonadotropins based on observations of physiologically relevant parameters such as age related glycosylation changes.

Table of Contents
Description
Open Access article
Publisher
Springer Open Choice
Journal
Book Title
Series
Reviews in Endocrine & Metabolic Disorders;12(4), pp:289-302.
PubMed ID
DOI
ISSN
1389-9155
EISSN