The design and manufacturing of aircraft wing spars are extremely important to aerospace manufacturing, particularly in enhancing manufacturing efficiency and sustainability. In the past, when creating spar production plans, engineers approached material selection and manufacturing process optimization as separate decisions, which often resulted in higher costs. This study presents a mixed-integer linear programming (MILP) framework that takes a more united approach to spar production. Several production case studies were developed using different material and process combinations. To support this analysis, data comparing dissimilar materials and their properties were compiled from existing literature. These case studies were assessed using the MILP framework to see how well they performed. The results show that an integrated approach to manufacturing can help engineers reduce waste, improve sustainability, and use materials more efficiently.