Adenosine modulation of dynorphin B release by hippocampal synaptosomes

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Authors
Loewen, Jonathan J.
Peters, Ralph I.
Terrian, David M.
Advisors
Issue Date
1992-04-17
Type
Article
Keywords
Research Support, U.S. Gov't, Non-P.H.S.
Research Projects
Organizational Units
Journal Issue
Citation
Brain research. 1992 Apr 17; 577(2): 318-20.
Abstract

A rat hippocampal preparation enriched in mossy fiber synaptosomes was employed in an attempt to expose any relationship between endogenous adenosine and the release of dynorphin B-like immunoreactivity (DynB-LI). Presumptive blockade of purinergic receptors increased the spontaneous release of DynB-LI, and reducing synaptic adenosine by exogenous adenosine deaminase increased the K(+)-evoked release. Evoked release of DynB-LI was reduced by inhibitors of adenosine uptake and 5'-nucleotidase. Taken together, these data suggest that adenosine endogenous to hippocampal mossy fiber synaptosomes serves to inhibit the release of one of the peptide neuromodulators of this preparation, and provide support for the concept of autoregulation of release.

Table of Contents
Description
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Publisher
Elsevier
Elsevier BV
Journal
Book Title
Series
Brain research
PubMed ID
DOI
ISSN
0006-8993
EISSN