Loading...
Fabrication and characterization of highly porous peek bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for scaffold applications
Dhanasekaran Swaminathan, Puttagounder
Dhanasekaran Swaminathan, Puttagounder
Files
Loading...
dissertation
Adobe PDF, 30.73 MB
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2013-05
Type
Dissertation
Genre
Keywords
Subjects (LCSH)
Electronic dissertations
Electronic dissertations
Electronic dissertations
Citation
Abstract
Bone regeneration has become essential due to various bone diseases, such as bone
infections, tumors and resultant bone fracture, birth defects, or bone loss due to trauma or
accident. Regeneration of bone is achieved by using a range of materials and scaffolds
manufactured through various fabrication techniques. Uses of different materials and scaffold
fabrication techniques have been explored over the past 20 years.
In this research, polyetheretherketone (PEEK) was used to fabricate highly porous
bionanocomposites foams for bone scaffolding. Melt casting and salt porogen (200–500 μm size)
leaching methods were adapted to have adequate pore size and the necessary percent of porosity,
because pore size plays a vital role in cell implantation and growth. Hydroxyapatite (HA) and
carbon particles were used to improve cell attachment to the PEEK foams and to increase the
mechanical properties of the materials. Carbon fiber (CF) and carbon nanotubes (CNTs) with
various weight percentages (wt %) were uniformly dispersed into the PEEK powder prior to the
casting, in order to enhance the mechanical and biological properties and to observe the
influence of the carbon particles on the properties of PEEK bionanocomposite foams.
Compression testing proved that HA and carbon particles improved the mechanical
properties. PEEK foam with 75% porosity and 0.5% CNT concentration showed higher elastic
modulus (225.91 MPa) compared to the neat PEEK (66.457 MPa), PEEK + HA (88.827 MPa),
and PEKK+ CF (215.05 MPa). Similar observations were seen on the yield stresses of the foam
materials. Bone marrow cell growth was observed on PEEK bionanocomposite foams, and a
carbon particle showed increased cell attachment over the neat PEEK. The mechanical and
biological tests proved that PEEK bionanocomposite foams fabricated via melt-casting and salt
porogen leaching have potential use for the bone scaffolding.
Table of Contents
Description
Thesis (Ph.D.)--Wichita State University, College of Engineering, Dept. of Mechanical Engineering
Publisher
Wichita State University
Journal
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
Copyright Puttagounder Dhanasekaran Swaminathan, 2013. All rights reserved