Linkage analysis of the hph-1 mutation and the GTP cyclohydrolase I structural gene

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Montañez, Cindy S.
McDonald, J. David

Molecular genetics and metabolism. 1999 Sep; 68(1): 91-2.


Our research establishes genetic linkage between the hph-1 mutation and the GTP-CH I structural gene. Our results indicate that these two loci are within an 8 cM region with 95% confidence. This finding lends additional support for the use of the hph-1 mouse mutant as a bona fide model system for the human disorder GTP-CH I to further our understanding of the molecular mechanisms involved in the disease pathology of GTP-CH I deficiency.

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