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Composite magnetic nanoparticle drug delivery system
Asmatulu, Ramazan Misak, Heath Edward Yang, Shang-You Wooley, Paul H.
Asmatulu, Ramazan
Misak, Heath Edward
Yang, Shang-You
Wooley, Paul H.
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WO/2012/051220
Adobe PDF, 2.14 MB
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2012-04-19
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Asmatulu, R., Misak, H.E., Yang, S., Wooley, P.H., inventors; Wichita State University, assignees. Composite magnetic nanoparticle drug delivery system. World Intellectual Property Organization WO/2012/051220. 2012, April 19.
Abstract
A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion/solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.
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WSU inventors: Ramazan Asmatulu, Heath Misak, Dept. of Mechanical Engineering, College of Engineering, Shang-You-Yang, Paul Wooley, Dept. of Biological Sciences, College of Liberal Arts and Sciences
International Application No: PCT/US2011/055847 filed October 11, 2011. Patent No: WO/2012/051220 granted April 19, 2012.
International Application No: PCT/US2011/055847 filed October 11, 2011. Patent No: WO/2012/051220 granted April 19, 2012.
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World Intellectual Property Organization
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Status: Publication 2012-04-19