Enantioselective inhibition of human leukocyte elastase
No Thumbnail Available
Authors
Groutas, William C.
Brubaker, Michael J.
Venkataraman, Radhika
Stanga, Michael A.
Advisors
Issue Date
1992-08-15
Type
Article
Keywords
Comparative Study , Research Support, U.S. Gov't, P.H.S.
Citation
Archives of biochemistry and biophysics. 1992 Aug 15; 297(1): 144-6.
Abstract
(RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined. The k2/KI values for the R and S isomers were found to be 330 and 1500 M-1 s-1, respectively.
Table of Contents
Description
Full text of this article is not available in SOAR.
Publisher
Elsevier
Journal
Book Title
Series
Archives of biochemistry and biophysics
Arch. Biochem. Biophys.
Arch. Biochem. Biophys.
PubMed ID
DOI
ISSN
0003-9861