Conformational Changes in Palladin Actin-Binding Domains Measured by Fluorescent Resonance Energy Transfer

dc.contributor.authorWomack, Samuel
dc.contributor.authorVattepu, Ravi
dc.contributor.authorBeck, Moriah R.
dc.date.accessioned2017-09-18T02:10:13Z
dc.date.available2017-09-18T02:10:13Z
dc.date.issued2017-04
dc.descriptionClick on the URL to access the article may not be free).en_US
dc.description.abstractThe fundamental goal of our research is to understand how cell motility in both normal and metastatic cells is regulated by palladin, an actin binding protein that plays a key role in remodeling the actin cytoskeleton. Our recent work has established that palladin regulates actin dynamics and organization by enhancing the polymerization rate and stabilizing filaments in an orthogonal meshwork. Palladin family members all utilize immunoglobulin-like domains to bind and crosslink actin filaments. Various isoforms of palladin contain from three to five immunoglobulin-like domains that have been implicated in a variety of protein-protein interactions.en_US
dc.description.sponsorshipInstitutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103418 and P20 GM103638 and an undergraduate research grant from Wichita State University.en_US
dc.identifier.citationSamuel Womack, Ravi Vattepu, and Moriah Rene Beck Conformational Changes in Palladin Actin-Binding Domains Measured by Fluorescent Resonance Energy Transfer FASEB J April 2017 31:762.10en_US
dc.identifier.issn0892-6638
dc.identifier.otherWOS:000405461403082
dc.identifier.urihttp://www.fasebj.org/content/31/1_Supplement/762.10
dc.identifier.urihttp://hdl.handle.net/10057/14089
dc.language.isoen_USen_US
dc.publisherFederation of American Societies for Experimental Biologyen_US
dc.relation.ispartofseriesFASEB Journal;v.31:no.1
dc.rights.holderCopyright © 2017 by the Federation of American Societies for Experimental Biologyen_US
dc.titleConformational Changes in Palladin Actin-Binding Domains Measured by Fluorescent Resonance Energy Transferen_US
dc.typeAbstracten_US
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