Inhibition of human leukocyte elastase and cathepsin G by isoxazoline derivatives
Groutas, William C. Chong, Lee S. Epp, Jeffrey B. Venkataraman, Radhika Brubaker, Michael J. Stanga, Michael A. Kim, Eun-hong Keller, Charles E.
Groutas, William C.
Chong, Lee S.
Epp, Jeffrey B.
Venkataraman, Radhika
Brubaker, Michael J.
Stanga, Michael A.
Kim, Eun-hong
Keller, Charles E.
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Issue Date
1992-12
Type
Article
Genre
Keywords
Cathepsin G,Leukocyte elastase,Cathepsin G,Enzyme inhibitor,Isoxazoline derivative,N Hydroxy 3 Phenyl 2 Isoxazoline 4,5 Dicarboximide,Unclassified drug,Article,Enzyme inhibition,Enzyme stability,Human,Protein binding,Structure activity relation
Subjects (LCSH)
Citation
William C. Groutas, Lee S. Chong, Jeffrey B. Epp, Radhika Venkataraman, Michael J. Brubaker, Michael A. Stanga, Eun-Hong Kim, Charles E. Keller, Inhibition of human leukocyte elastase and cathepsin G by isoxazoline derivatives, Bioorganic & Medicinal Chemistry Letters, Volume 2, Issue 12,1992, Pages 1571-1574, ISSN 0960-894X,https://doi.org/10.1016/S0960-894X(00)80432-1.
Abstract
The interaction of a series of derivatives of cis-N-hydroxy-3-phenyl-2-isoxazoline-4,5-dicarboximide toward human leukocyte elastase and cathepsin G was investigated. Both enzymes were rapidly acylated and the corresponding acyl enzymes exhibited variable stability. © 1992. © 2014 Elsevier B.V., All rights reserved.
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Publisher
Elsevier
Journal
Bioorganic and Medicinal Chemistry Letters
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PubMed ID
ISSN
1464-3405
0960-894X
0960-894X