This is a paper that investigates how major problems in corporations can occur if the Management of Technology is not properly administered. The purpose of this paper is to review large firms and people that relied on technology and who had serious failures caused by mismanagement. Such mismanagement had a variety of causes such as incompetence, poor ethics, abuse, and outright corruption. Over the years there have been individuals and firms who have been seriously sanctioned based on crimes such as fraud. This paper focuses on some of the most egregious cases that have occurred during the past four decades. This manuscript documents a considerable number of major corporations that experienced such problems and suffered subsequent profound consequences. Two that are examined in detail are Volkswagen and Theranos. These two firms provide significant illustrations of how mismanagement of technology was a prime factor that caused catastrophic failure in their operations. Enough other big firms that are cited lead to the inference that mismanagement of technology was involved on a major scale.