Incidence and risk factors of fellow-eyes wet conversion in unilateral neovascular age-related macular degeneration over 15-year follow-up

No Thumbnail Available
Authors
Sadeghi, Elham
Vupparaboina, Sharat Chandra
Bollepalli, Sandeep Chandra
Vupparaboina, Kiran
Agarwal, Komal
Sahel, Jose-Alain
Eller, Andrew W.
Chhablani, Jay
Advisors
Issue Date
2024-08-23
Type
Article
Keywords
Age-related macular degeneration , Dry AMD , Fellow eye , Neovascular AMD
Research Projects
Organizational Units
Journal Issue
Citation
Sadeghi, E., Vupparaboina, S.C., Bollepalli, S.C. et al. Incidence and risk factors of fellow-eyes wet conversion in unilateral neovascular age-related macular degeneration over 15-year follow-up. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06605-8
Abstract

Purpose: Incidence and risk factors of fellow eye wet conversion in unilateral neovascular age-related macular degeneration (nAMD) over 15-years follow-up. Methods: This retrospective study reviewed 593 unilateral nAMD patients with a minimum of five years up to 15-years of follow-up. The demographic data, visual acuity, fellow eye nAMD conversion rate, and the number of anti-vascular endothelial growth factor (anti-VEGF) injections in the primary eye were evaluated. Also, the nAMD-converted fellow eyes were divided into two groups based on the time of conversion (less and more than two years from the first injection in the primary eye). Based on the data types, the T-test, Chi-square, and Mann-Whitney U test were used to analyze. Results: The total cases were 593 patients, and 248 eyes (41.82%) converted to nAMD in the mean interval of 34.92 ± 30.62months. The males exhibited a predisposition to wet conversion at 2.54years earlier than their female counterparts (P = 0.025). In all the converted fellow eyes, the mean age was 2.3years higher at presentation in the group who converted within two years of follow-up in compared to eyes that converted after two years (79.82 ± 8.64 vs 77.51 ± 8.5years, P = 0.035). Additionally, eyes converting within two years had a mean baseline LogMAR visual acuity of 0.44 ± 0.47, compared to 0.32 ± 0.41 for conversions after two years (P = 0.014). Conclusion: This study reported that males showed a predisposition to fellow eye nAMD conversion at an earlier age. Additionally, there was a trend of faster fellow eye nAMD conversion in individuals with higher age and lower baseline visual acuity. Key messages: What is known • Certain risk factors may make the fellow eye of neovascular age-related macular degeneration (nAMD) more likely to progress to wet conversion. • Identifying these risk factors for fellow eye wet conversion can help prevent it, potentially preserving the patient's vision quality for a longer duration. • The studies on the incidence of wet conversion in the fellow eye have yielded controversial results. What is new • During the 15-year follow-up period, nearly half (47.58%) of the fellow eyes that underwent wet conversion did so within the initial two years following the wet conversion of the first eye. • Males showed a predisposition to fellow eye nAMD conversion at an earlier age. • There was a trend of faster fellow eye nAMD conversion in individuals with higher age and lower baseline visual acuity. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

Table of Contents
Description
Click on the DOI link to access the article (may not be free).
Publisher
Springer Science and Business Media Deutschland GmbH
Journal
Graefe's Archive for Clinical and Experimental Ophthalmology
Book Title
Series
PubMed ID
ISSN
0721-832X
EISSN