According to the National Center for Health Statistics in 2004 over 478,000 people Underwent Total Knee Replacement surgeries in 2004. The number is rapidly growing due to advances in implant surgeries, knee implants, and longevity but is limited to patients older than 60 years. Knee implant surgery failures have also increased which has lead to increased number of revisions. Recent attempts have been made to design and optimize customized knee implants for young patients and provide a solution for current failures in knee replacements. The objective of this research is to compare the femoral components of customized and traditional implant designs using femur bone interface. The comparison was made using three load levels of body weight acting on the femur bone with attached femoral components at two gait angles with four orthopaedic materials. Statistical analysis was conducted using a general factorial design to quantify the effect of these factors. Finite Element Analysis (FEA) was performed to measure the maximum stress level (_max) for design comparison. The statistical analysis concluded that the two-factor interaction involving knee design and angle had a significant effect on the average stress level. Based on the assumptions the FEA results indicated that the femoral component of the traditional knee implant design was better than the customized knee implant design with respect to maximum stress level (o-max)