The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3
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Authors
Groutas, William C.
Chong, Lee S.
Venkataraman, Radhika
Epp, Jeffrey B.
Kuang, Rongze
Houser-Archield, Nadene
Hoidal, John R.
Advisors
Issue Date
1995-02-01
Type
Article
Keywords
Research Support, Non-U.S. Gov't , Research Support, U.S. Gov't, P.H.S.
Citation
Bioorganic & medicinal chemistry. 1995 Feb; 3(2): 187-93.
Abstract
The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.
Table of Contents
Description
Full text of this article is not available in SOAR.
Publisher
Elsevier
Journal
Book Title
Series
Bioorganic & medicinal chemistry
Bioorg. Med. Chem.
Bioorg. Med. Chem.
PubMed ID
DOI
ISSN
0968-0896