This paper considers an amplify-and-forward (AF) relay scheme for M-source-M-destination pairs and N relay nodes. Cooperative minimum mean square error (MMSE) strategies for wireless relay networks under both a jamming environment and channel uncertainty with received power constraints at the destination nodes are studied. The main contribution of this paper is the derivation of the MMSE-based amplifying relay matrices (ARMs) under both a jamming environment and channel uncertainty. With the proposed ARMs, the system performance under study is evaluated by observing bit error rate (BER) using Monte Carlo simulations. In addition, it is proven that the proposed ARM is the global optimal ARM.