Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

Loading...
Thumbnail Image
Authors
Mahapatro, Anil
Singh, Dinesh K.
Issue Date
2011-11
Type
Article
Language
en_US
Keywords
Biodegradable , Nanoparticles , Polyesters , Vaccine delivery , Drug delivery , Gene delivery
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract

Biodegradable nanoparticles (NPs) are gaining increased attention for their ability to serve as a viable carrier for site specific delivery of vaccines, genes, drugs and other biomolecules in the body. They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, vaccines and biomolecules to be used in a variety of applications in the field of medicine. In this manuscript, the methods of preparation of biodegradable NPs, different factors affecting optimal drug encapsulation, factors affecting drug release rates, various surface modifications of nanoparticles to enhance in-vivo circulation, distribution and multimodal functionalities along with the specific applications such as tumor targeting, oral delivery, and delivery of these particles to the central nervous system have been reviewed.

Description
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation
Mahapatro and Singh: Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines. Journal of Nanobiotechnology. 2011; 9: 55. Published online 2011 November 28. doi: 10.1186/1477-3155-9-55
Publisher
BioMed Central
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
1477-3155
EISSN