As a result of the coronavirus disease 2019 (COVID-19) public health emergency, the airline industry had implemented additional measures to disinfect aircraft interiors. This involved frequent use of disinfectant products on aircraft cabin and seating materials. In this paper, the long-term effects of exposing honeycomb sandwich panels to disinfectant products are presented. The disinfectant methods considered for this study are chemical and ultraviolet-c germicidal irradiation. Five different chemical disinfectants commonly used in the airline industry and three different ultraviolet-c wavelength configurations were selected. Accelerated aging tests with various disinfectant configurations were conducted on honeycomb sandwich specimens and the subsequent effects on mechanical and physical performance are investigated. © 2023, American Institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.