Anti-norovirus therapeutics: a patent review (2010-2015)

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Authors
Kankanamalage, Anushka C. Galasiti
Weerawarna, Pathum M.
Kim, Yunjeong
Chang, Kyeong-Ok
Groutas, William C.
Advisors
Issue Date
2016-03-03
Type
Article
Keywords
3CL protease inhibitors , RdRp inhibitors , Attachment and entry inhibitors , Norovirus infection , Host factors
Research Projects
Organizational Units
Journal Issue
Citation
Kankanamalage, Anushka C. Galasiti; Weerawarna, Pathum M.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. 2016. Anti-norovirus therapeutics: a patent review (2010-2015). Expert Opinion on Therapeutic Patents, vol. 26:no. 3:pp 297-308
Abstract

Introduction: Human noroviruses are the primary causative agents of acute gastroenteritis and are a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or prophylaxis of norovirus infections. An improved understanding of norovirus biology, as well as the pathogenic mechanisms underlying the disease, has provided the impetus for a range of intense exploratory drug discovery efforts targeting viral and host factors.

Areas covered: An overview of norovirus inhibitors disclosed in the patent literature (2010-present) and Clinicaltrials.gov is presented. The review is further enriched and supplemented by recent literature reports.

Expert opinion: Seminal discoveries made in recent years, including a better understanding of the pathobiology and life cycle of norovirus, the identification and targeting of multiple viral and host factors, the advent of a replicon system and a small animal model for the preclinical evaluation of lead compounds, and the availability of high resolution X-ray crystal structures that can be utilized in structure-based drug design and lead optimization campaigns, collectively suggest that a small molecule therapeutic and prophylactic for norovirus infection is likely to emerge in the not too distant future.

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Publisher
Taylor & Francis Group
Journal
Book Title
Series
Expert Opinion on Therapeutic Patents;v.26:no.3
PubMed ID
DOI
ISSN
1354-3776
EISSN