Chapter 3 -- Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+

dc.contributor.authorWimalasena, Kandatege
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractAmong Parkinson's disease (PD) toxin models, MPTP/MPP+ has been the most popular, extensively characterized, and widely used to identify the cellular mechanisms associated with the selective degeneration of dopaminergic neurons in PD. A number of recent studies have found some gaps and weaknesses in the generally accepted mechanism especially with regard to the selective dopaminergic toxicity of the model. Accumulating evidence suggests that the inherent physiological predisposition of dopaminergic neurons to generate high oxidative stress, especially when exposed to various environmental and genetic factors and their inability to cope with these conditions effectively, could contribute to their selective destruction. However, the current models for the selective dopaminergic toxicity of MPTP/MPP+ have not taken into account the unique susceptibilities of these neurons. The focus of this chapter is to discuss the discovery, current status, gaps, and weaknesses of the mechanism of the specific dopaminergic toxicity of the MPTP/MPP+ model.en_US
dc.identifier.citationWimalasena, Kandatege. 2017. Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+. In: Advances in Molecular Toxicology, vol. 11:pp 81-122en_US
dc.relation.ispartofseriesAdvances in Molecular Toxicology;v.11
dc.rights.holderCopyright © 2017 Elsevier B.V. All rights reserved.en_US
dc.subjectNeurotoxic tetrahydro-β-carbolinesComplex I inhibitionReactive oxygen speciesDopamineDopamine transporterVesicular monoamine transporterMonoamine oxidaseen_US
dc.subjectParkinson's diseaseen_US
dc.subjectMPTP/MPP+ PD modelen_US
dc.subjectNeurotoxic tetrahydroisoquinolinesen_US
dc.subjectNeurotoxic tetrahydro-β-carbolinesen_US
dc.subjectComplex I inhibitionen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectDopamine transporteren_US
dc.subjectVesicular monoamine transporteren_US
dc.subjectMonoamine oxidaseen_US
dc.titleChapter 3 -- Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+en_US
dc.typeBook chapteren_US
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