Potential inhibitors of dengue and West Nile virus proteases

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Issue Date
2006-07
Authors
Mohan, Swathi
Advisor
Groutas, William C.
Citation
Abstract

The 1,2,5-Thiadiazolidin-3-one 1,1-dioxide scaffold was used in the design and synthesis of inhibitors of Dengue Virus and West Nile Virus proteases and human tryptase. The scaffold was successfully used in the synthesis of potential inhibitors of Dengue Virus and West Nile Virus proteases. Inhibitors of Human tryptase synthesized based on the 1,2,5-Thiadiazolidin-3-one 1,1- dioxide scaffold were shown to be effective mechanism-based inhibitors of the enzyme.

Table of Content
Description
Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry.
"July 2006."
Includes bibliographic references (leaves 64-66).
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