An intravaginal device configured to be deployed within a vaginal tract of a patient for treating, reducing risks associated with, and/or preventing sexually transmitted infection includes a body having a flexible biocompatible material. The intravaginal device also includes: a flexible sensor array embedded in the body having at least one of a sodium sensor or pH sensor; a reservoir embedded in the body including a therapeutic agent configured to be released by an electro-responsive electrode assembly; and a near field communication circuit configured for wireless communication with an external device for wireless charging, data transmission, and receipt of control signals. The intravaginal device also includes a device controller configured to activate the electro-responsive electrode assembly to release the therapeutic agent from the reservoir in response to signals detected by the flexible sensor array and/or control signals received from the external device via the near field communication circuit.