Genetic destabilization of Candida albicans by hydroxyurea

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Authors
Sarachek, Alvin
Henderson, Lori A.
Eddy, K. B.
Issue Date
1991
Type
Article
Language
eng
Keywords
Research Support, Non-U.S. Gov't
Research Projects
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Abstract

Candida albicans is a commensal component of the normal human microflora, but frequently causes infections in persons undergoing treatment for malignancies. The cytotoxicity and genotoxicity of the antineoplastic agent hydroxyurea (HU) for the yeast is demonstrated. Cultivation of the organism on defined complete medium in the presence of HU induced growth inhibition or cell death, gene mutations, segregations of heterozygous loci through reciprocal and nonreciprocal mitotic recombinations, and a special heritable system for high frequency switching between phenotypes reflecting cellular growth characteristics and susceptibilities to HU. Each of these responses is influenced differently by variations in drug concentration and temperature. The biochemical complexity underlying cytotoxic and genetic effects of HU, and the implications for the likelihood of HU induced changes occurring in indigenous yeast populations of persons undergoing therapy with the drug, are discussed.

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The full text of this article is not available in SOAR.
Citation
Microbios. 1991; 65(262): 39-61.
Publisher
University of Cambridge * Faculty Press
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PubMed ID
DOI
ISSN
0026-2633
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