Follicle-stimulating hormone biological products: Does potency predict clinical efficacy?

dc.contributor.authorLispi, Monica
dc.contributor.authorHumaidan, Peter
dc.contributor.authorBousfield, George R.
dc.contributor.authorD'Hooghe, Thomas
dc.contributor.authorUlloa-Aguirre, Alfredo
dc.date.accessioned2023-06-06T21:47:03Z
dc.date.available2023-06-06T21:47:03Z
dc.date.issued2023-05-19
dc.descriptionThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractFollicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding of reproduction and led to the development of many treatments for infertility. In this regard, exogenous FSH has been used to treat infertility in women for decades. Today, several recombinant and highly purified urinary forms of FSH are used in medically assisted reproduction (MAR). However, differences in the macro- and micro-heterogeneity of FSH result in a variety of FSH glycoforms, with glycoform composition determining the bioactivity (or potency), pharmacokinetic/pharmacodynamic (PK/PD) profiles, and clinical efficacy of the different forms of FSH. This review illustrates how the structural heterogeneity of FSH glycoforms affects the biological activity of human FSH products, and why potency does not predict effects in humans in terms of PK, PD, and clinical response.
dc.identifier.citationLispi, M.; Humaidan, P.; Bousfield, G.R.; D'Hooghe, T.; Ulloa-Aguirre, A. Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy? Int. J. Mol. Sci. 2023, 24, 9020. https://doi.org/10.3390/ijms24109020
dc.identifier.issn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms24109020
dc.identifier.urihttps://soar.wichita.edu/handle/10057/25377
dc.language.isoen_US
dc.publisherMDPI
dc.relation.ispartofseriesInternational Journal of Molecular Sciences
dc.relation.ispartofseriesVolume 24, No. 10
dc.rights.holder© 2023 by the authors. Licensee MDPI, Basel, Switzerland.
dc.subjectFollicle-stimulating hormone
dc.subjectGlycoform
dc.subjectGonadotropin
dc.subjectHeterogeneity
dc.subjectPotency
dc.subjectReproduction
dc.subjectSialylation
dc.titleFollicle-stimulating hormone biological products: Does potency predict clinical efficacy?
dc.typeReview
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