Broad spectrum antivirals against coronavirus
Chang, Kyeong-Ok Kim, Yunjeong Groutas, William C. Perlman, Stanley
Chang, Kyeong-Ok
Kim, Yunjeong
Groutas, William C.
Perlman, Stanley
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2026-03-24
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Chang, K., Kim, Y., Groutas, W. C., & Perlman, S. Broad spectrum antivirals against coronavirus. United States patent 12,583,820 B2. 2026, March 24.
Abstract
Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picomavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2 is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C1 -C6 hydroxyalkyl, aldehydes, alpha-ketoamides, and bisulfite salts, and in particular ----CH2OH, -CHO, ----CH(0H)S03 - Na+, and -[0(C=0)Rw]S03 -Na+.
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WSU inventors: Groutas, William C., Dept. of Chemistry, College of Liberal Arts and Sciences
Application No: 17/907,745 filed March 30, 2021. Patent No: US 12,583,820 B2 granted March 24, 2026.
Application No: 17/907,745 filed March 30, 2021. Patent No: US 12,583,820 B2 granted March 24, 2026.
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United States Patent and Trademark Office
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Status: Patented Case