FGDB: Database of follicle stimulating hormone glycans

Loading...
Thumbnail Image
Authors
Shakyawar, Sushil K.
Pandey, Sanjit
Harvey, David J.
Bousfield, George R.
Guda, Chittibabu
Issue Date
2021
Type
Article
Language
en_US
Keywords
Follicle stimulating hormones , (FSH)Glycan structures , Glycoprotein database , Glycomics , Glycan abundance analysis
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract

Glycomics, the study of the entire complement of sugars of an organism has received significant attention in the recent past due to the advances made in high throughput mass spectrometry technologies. These analytical advancements have facilitated the characterization of glycans associated with the follicle-stimulating hormones (FSH), which play a central role in the human reproductive system both in males and females utilizing regulating gonadal (testicular and ovarian) functions. The irregularities in FSH activity are also directly linked with osteoporosis. The glycoanalytical studies have been tremendously helpful in understanding the biological roles of FSH. Subsequently, the increasing number of characterized FSH glycan structures and related glycoform data has thrown a challenge to the glycoinformatics community in terms of data organization, storage and access. Also, a user-friendly platform is needed for providing easy access to the database and performing integrated analysis using a high volume of experimental data to accelerate FSH-focused research.

FSH Glycans DataBase (FGDB) serves as a comprehensive and unique repository of structures, features, and related information of glycans associated with FSH. Apart from providing multiple search options, the database also facilitates an integrated user-friendly interface to perform the glycan abundance and comparative analyses using experimental data. The automated integrated pipelines present the possible structures of glycans and variants of FSH based on the input data, and allow the user to perform various analyses. The potential application of FGDB will significantly help both glycoinformaticians as well as wet-lab researchers to stimulate the research in this area.

Description
© 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license.
Citation
Shakyawar, S. K., Pandey, S., Harvey, D. J., Bousfield, G., & Guda, C. (2021). FGDB: Database of follicle stimulating hormone glycans. Computational and Structural Biotechnology Journal, 19, 1635-1640. doi:10.1016/j.csbj.2021.03.009
Publisher
Elsevier
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
2001-0370
EISSN