ENU mutagenesis in the mouse

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Issue Date
2004-02
Authors
McDonald, J. David
Beier, David R.
Advisor
Citation

Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]. 2004 Feb; Chapter 15: Unit 15.4.

Abstract

This unit describes the treatment of laboratory mice with the mutagen N-ethyl-N-nitrosourea (ENU) to achieve very highly induced rates of mutation throughout the genome. Further, it describes several popular mating schemes designed to produce animals displaying phenotypes associated with the induced mutations.

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