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dc.contributor.authorPrior, Allan M.
dc.contributor.authorKim, Yunjeong
dc.contributor.authorWeerasekara, Sahani
dc.contributor.authorMoroze, Meghan
dc.contributor.authorAlliston, Kevin R.
dc.contributor.authorUy, Roxanne Adeline Z.
dc.contributor.authorGroutas, William C.
dc.contributor.authorChang, Kyeong-Ok
dc.contributor.authorHua, Duy H.
dc.identifier.citationPrior, Allan M.; Kim, Yunjeong; Weerasekara, Sahani; Moroze, Meghan; Alliston, Kevin R.; Uy, Roxanne Adeline Z.; Groutas, William C.; Chang, Kyeong-Ok; Hua, Duy H. 2013. Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors. Bioorganic & Medicinal Chemistry Letters, vol. 23:no. 23:pp. 6317-6320, 1 December 2013en_US
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractA class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array of warheads, including aldehyde, a-ketoamide, bisulfite adduct, and a-hydroxyphosphonate transition state mimic, was also investigated. Tripeptidyls 2 and 6 possess antiviral activities against noroviruses, human rhinovirus, severe acute respiratory syndrome coronavirus, and coronavirus 229E, suggesting a broad range of antiviral activities.en_US
dc.description.sponsorshipNIH Grant U01AI081891. Moroze was funded through the ASSURE program of the Department of Defense in partnership with the NSF REU Site program number 1004991.en_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofseriesBioorganic & Medicinal Chemistry Letters;v.23:no.23
dc.subjectViral 3C and 3C-like protease inhibitorsen_US
dc.subjectHuman rhinovirusen_US
dc.subjectCoronavirus 229Een_US
dc.subjectSevere acute respiratory syndrome coronavirusen_US
dc.titleDesign, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitorsen_US
dc.rights.holderCopyright © 2013 Elsevier Ltd.

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