• Login
    View Item 
    •   Shocker Open Access Repository Home
    • Engineering
    • Mechanical Engineering
    • ME Research Publications
    • View Item
    •   Shocker Open Access Repository Home
    • Engineering
    • Mechanical Engineering
    • ME Research Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Cytotoxicity of magnetic nanocomposite spheres for possible drug delivery systems

    Date
    2012
    Author
    Asmatulu, Ramazan
    Garikapati, Anusha
    Misak, Heath Edward
    Song, Zheng
    Yang, Shang-You
    Wooley, Paul H.
    Metadata
    Show full item record
    Citation
    Asmatulu, Ramazan; Garikapati, Anusha; Misak, Heath Edward; Song, Z.; Yang, Shang-You; Wooley, Paul H. 2012. Cytotoxicity of magnetic nanocomposite spheres for possible drug delivery systems. ASME 2010 International Mechanical Engineering Congress and Exposition Volume 10: Micro and Nano Systems Vancouver, British Columbia, Canada, November 12–18, 2010, Paper No. IMECE2010-40269, pp. 911-918:8 pages
    Abstract
    Cytotoxicity test is a rapid and standardized in vitro method to determine the harmful effects of materials used for biomedical purposes, such as drug carriers, implants and their coatings, biosensors and surgical/medical devices. In the present study, sol-gel driven nickel ferrite (NiFe2O4) and cobalt ferrite (CoFe2O4) nanoparticles (10-25 nm) at different concentrations were incorporated into biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), using oil-in-oil emulsion/solvent evaporation technique, and then the cytotoxicity of magnetic nanocomposite spheres was characterized using raw cells. The test provides the toxicity of the products prior to their real applications, which may limit animal experimentation, remove potential toxic compounds and reduce the downstream costs. The cytotoxicity results showed that both magnetic nanocomposite spheres were toxic at some degree to the raw cells; however, the cobalt ferrite nanoparticles in nanocomposite spheres are more toxic than the nickel ferrite nanoparticles.
    Description
    Click on the DOI link to access the article (may not be free).
    URI
    http://dx.doi.org/10.1115/IMECE2010-40269
    http://hdl.handle.net/10057/6140
    Collections
    • ME Research Publications

    Browse

    All of Shocker Open Access RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Type

    My Account

    LoginRegister

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV