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dc.contributor.authorGe, Jianhua
dc.contributor.authorLi, Musen
dc.contributor.authorZhang, Qingguo
dc.contributor.authorYang, Christopher Z.
dc.contributor.authorWooley, Paul H.
dc.contributor.authorChen, Xiaofeng
dc.contributor.authorYang, Shang-You
dc.date.accessioned2013-08-12T18:53:48Z
dc.date.available2013-08-12T18:53:48Z
dc.date.issued2013-06-18
dc.identifier.citationJianhua Ge, Musen Li, Qingguo Zhang, et al., “Silica Aerogel Improves the Biocompatibility in a Poly-epsilon-caprolactone Composite Used as a Tissue Engineering Scaffold,” International Journal of Polymer Science, vol. 2013, Article ID 402859, 7 pages, 2013. doi:10.1155/2013/402859en_US
dc.identifier.issn1687-9422
dc.identifier.otherWOS:000321850200001
dc.identifier.urihttp://dx.doi.org/10.1155/2013/402859
dc.identifier.urihttp://hdl.handle.net/10057/6139
dc.descriptionCopyright © 2013 Jianhua Ge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.description.abstractPoly-epsilon-caprolactone (PCL) is a biodegradable polyester that has received great attentions in clinical and biomedical applications as sutures, drug delivery tool, and implantable scaffold material. Silica aerogel is a material composed of SiO2 that has excellent physical properties for use in drug release formulations and biomaterials for tissue engineering. The current study addresses a composite of silica aerogel with PCL as a potential bone scaffold material for bone tissue engineering. The biocompatibility evaluation of this composite indicates that the presence of silica aerogel effectively prevented any cytotoxic effects of the PCL membrane during extended tissue culture periods and improved the survival, attachment, and growth of 3T3 cells and primary mouse osteoblastic cells. The beneficial effect of silica aerogel may be due to neutralization of the acidic condition that develops during PCL degradation. Specifically, it appears that silica aerogel to PCL wt/wt ratio at 0.5:1 maintains a constant pH environment for up to 4 weeks and provides a better environment for cell growth.en_US
dc.description.sponsorshipNational Science Funds of China (51072055, 50830101, and CB606204), the Science Funds of Shandong Province (BS2010YY020, ZR2009FM023), and funds from the Orthopaedic Research Institute, Via Christi Wichita Hospitals, Inc.en_US
dc.language.isoen_USen_US
dc.publisherHindawien_US
dc.relation.ispartofseriesInternational Journal of Polymer Science;v.2013:article 402859
dc.subjectDrug-deliveryen_US
dc.subjectIn-vitroen_US
dc.subjectMechanical propertiesen_US
dc.subjectAttachmenten_US
dc.subjectGlassesen_US
dc.subjectFilmsen_US
dc.subjectPCLen_US
dc.titleSilica aerogel improves the biocompatibility in a Poly-epsilon-caprolactone composite used as a tissue engineering scaffolden_US
dc.typeArticleen_US
dc.description.versionPeer reviewed
dc.rights.holderCopyright 2013 Authors. Open Access distributed under the Creative Commons Attribution License


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