Gonadotropins and the importance of glycosylation
Dias, James A.
Bousfield, George R.
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Ulloa-Aguirre, A., Dias, J. A. and Bousfield, G. R. (2009) Gonadotropins and the Importance of Glycosylation, in Post-translational Modification of Protein Biopharmaceuticals (ed G. Walsh), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527626601.ch5
From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. As a result, around half of the book is devoted to protein glycosylation, while the remainder is made up of other modifications, such as carboxylation, hydroxylation, sulfation, amidation and proteolytic processing. A final section addresses the latest trend of engineering the modification pattern to improve a given biopharmceutical, presenting several recent case studies of successful posttranslational engineering. This first authoritative overview of the topic is an indispensable guide for drug developers and drug manufacturers with an interest in protein pharmaceuticals.
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