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dc.contributor.authorYang, Shang-You
dc.contributor.authorYu, Haiying
dc.contributor.authorKrygier, Jeffrey E.
dc.contributor.authorWooley, Paul H.
dc.contributor.authorMott, Michael P.
dc.date.accessioned2013-07-15T16:21:16Z
dc.date.available2013-07-15T16:21:16Z
dc.date.issued2007-10-19
dc.identifier.citationShang-You Yang, Haiying Yu, Jeffrey E. krygier, Paul H. Wooley, and Michael P. Mott, “High VEGF with Rapid Growth and Early Metastasis in a Mouse Osteosarcoma Model,” Sarcoma, vol. 2007, Article ID 95628, 7 pages, 2007. doi:10.1155/2007/95628en_US
dc.identifier.issn1357-714X
dc.identifier.issn1369-1643 (Electronic)
dc.identifier.otherArticle ID 95628
dc.identifier.urihttp://dx.doi.org/10.1155/2007/95628
dc.identifier.urihttp://hdl.handle.net/10057/5964
dc.descriptionClick on the DOI link to access this articleen_US
dc.description.abstractA murine model of osteosarcoma was developed to investigate the association between the expression of VEGF and the progression of osteosarcoma. Two human osteosarcoma cell lines with distinct VEGF expressions were introduced into proximal tibiae of immuno-deficient SCID mice, either by direct injection through the cortical bone or surgical exposing and drilling on the tibial metaphysis to seed tumor cells. Bone tumors were obvious on microCT within 4 weeks following osteosarcoma cell inoculation through surgical delivery. In contrast, direct injection without drilling often resulted in periosteal tumors. Although neoplasms were developed regardless of VEGF levels, orthotopic tumors derived from high VEGF-expressing cells were detected 2 weeks earlier on CT images than the ones from VEGF negative cells. At sacrifice, high VEGF tumors were distinctively larger in size and more frequently invaded the adjacent bone tissue. Multiple metastatic lesions were found in all the lung tissues at 8 weeks from high VEGF group, whereas only 1 of 7 VEGF negative tumors exhibited pulmonary metastasis. Overall, this model developed with the surgical tumor cell delivery results in histological and radiographic features more consistent with primary osteosarcoma. Interestingly, VEGF expression correlates with the early establishment, rapid tumor growth, and the development of pulmonary metastasis.en_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofseriesSarcoma;
dc.relation.ispartofseries;V.2007
dc.titleHigh VEGF with rapid growth and early metastasis in a mouse osteosarcoma modelen_US
dc.typeArticleen_US


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