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dc.contributor.authorLammli, John
dc.contributor.authorFan, Minyan
dc.contributor.authorRosenthal, Howard G.
dc.contributor.authorPatni, Meghan
dc.contributor.authorRinehart, Elizabeth
dc.contributor.authorWooley, Paul H.
dc.contributor.authorLucas, George
dc.contributor.authorYang, Shang-You
dc.date.accessioned2013-07-08T19:36:51Z
dc.date.available2013-07-08T19:36:51Z
dc.date.issued2012-11
dc.identifier.citationJohn Lammli, Minyan Fan, Howard G. Rosenthal, Meghan Patni, Elizabeth Rinehart, Gerardo Vergara, Elizabeth Ablah, Paul H. Wooley, George Lucas, Shang-You Yang; International Orthopaedics November 2012, Volume 36, Issue 11; P.2307-2313en_US
dc.identifier.issn0341-2695 (Print)
dc.identifier.issn1432-5195 (Electronic)
dc.identifier.urihttp://dx.doi.org/10.1007/s00264-012-1629-z
dc.identifier.urihttp://hdl.handle.net/10057/5882
dc.descriptionClick on the DOI link to access this article at the publisher's website (may not be free)en_US
dc.description.abstractPurpose Osteosarcoma is the most common primary malignancy in orthopaedic surgery. Studies suggest that expression of VEGF and high vascularity within osteosarcoma may correlate with poor prognosis. The purpose of this study was to determine whether there was a correlation of VEGF expression with clinical tumour stage and metastasis. Methods This retrospective case series examined 54 cases of osteosarcoma patients who were treated during a ten-year period. Relevant clinical information included age, gender, tumour location, stage, adjuvant therapy, morbidity, mortality, and tumour subtypes. The clinical information was analysed for correlation of VEGF expression and tumour prognosis. Tumour sections were examined by routine H&E and by immunohistochemistry for VEGF, CD31, and the oncogenes c-myc and c-fos. Results There was a significantly positive correlation between VEGF expression and tumour stages among these cases (p < 0.01). The data also suggested a higher cancer recurrence and more frequent cases of remote metastasis in the high-VEGF group compared to the low-VEGF group. VEGF expression also positively associated with c-fos and c-myc expressions in the primary tumour sections. Conclusion The results of this study highlight the role of VEGF in angiogenesis and tumour burden. Data also suggest the influence of VEGF may associate with the elevations of c-fos and c-myc expression. The development of novel therapies to target the VEGF pathway in osteosarcoma may lead to improved survival.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofseriesInternational Orthopaedics;
dc.relation.ispartofseries;V.36, No.3
dc.titleExpression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcomaen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed
dc.rights.holder© Springer-Verlag 2012


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