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dc.contributor.authorJiang, Yunpeng
dc.contributor.authorJia, Tanghong
dc.contributor.authorWooley, Paul H.
dc.contributor.authorYang, Shang-You
dc.identifier.citationJiang Y, Jia T, Wooley PH, Yang SY. Current research in the pathogenesis of aseptic implant loosening associated with particulate wear debris. Acta Orthop Belg. 2013 Feb;79(1):1-9. Review. PubMed PMID: 23547507.en_US
dc.identifier.otherPMID: 23547507
dc.descriptionClick on the URI link to access this article at the publisher's website (may not be free)en_US
dc.description.abstractPeriprosthetic osteolysis is the most common long-term complication of a total joint arthroplasty, often resulting in aseptic loosening of the implant, which occurs in up to 34% of younger implant recipients and usually requires surgical revision. Particulate wear debris, continuously generated by articulating motion at the bearing surfaces, has been implicated as one of the primary causes of periprosthetic bone loss and implant loosening. With developing implants and bearing surfaces designs, various types of wear particles with specific chemical nature, dimension and shape are formed, which may initiate different immune or inflammatory responses. Wear debris induces down-regulation or up-regulation of various pro-inflammatory cytokines and chemokines in a range of cell types at the interface between implants and the surrounding bone, such as macrophages, osteoclast precursor cells, osteoblasts, lymphocytes, fibroblasts etc. Concomitantly, these mediators further affect functions of cells through distinct signaling mechanisms in either an autocrine or a paracrine manner. This review summarizes current concepts of how wear debris causes osteolysis, and describes the interaction and effects of wear debris on functions of primary cell types involved in osteolysis.en_US
dc.description.sponsorshipThis work was supported by research grants from National Institutes of Health (5R03AR054929, S.-Y.Y.) and Orthopaedic Research & Education Foundation (S.-Y.Y.).en_US
dc.publisherActa Orthopaedica Belgicaen_US
dc.relation.ispartofseriesActa Orthop Belg.;V.79, No.1
dc.subjectWear debrisen_US
dc.subjectAseptic looseningen_US
dc.subjectArthroplasty failureen_US
dc.subjectBiological reactionen_US
dc.titleCurrent research in the pathogenesis of aseptic implant loosening associated with particulate wear debrisen_US
dc.rights.holder© 1950-2013 Acta Orthopaedica Belgica | Non-Profit Organization, All rights reserved

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