Now showing items 1-7 of 7

    • 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives 

      Groutas, William C.; Kuang, Rongze (United States Patent and Trademark Office, 2002-07-16)
      Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
    • Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C.; Hua, Duy; Saif, Linda J. (United States Patent and Trademark Office, 2016-10-25)
      Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the ...
    • Latent isocynate derivatives useful for deactivating enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 1990-05-29)
      Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ...
    • Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C. (United States Patent and Trademark Office, 2016-04-12)
      Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ...
    • Serine protease inhibitors 

      Groutas, William C. (United States Patent and Trademark Office, 1996-08-27)
      Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.
    • Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 2002-12-17)
      Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ...
    • Viral and fungal inhibitors 

      Padmanabhan, Radhakrishnan; Groutas, William C.; Korba, Brent E (United States Patent and Trademark Office, 2013-08-20)
      Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ...