Browsing Fairmount College of Liberal Arts and Sciences by Subject "a-Hydroxyphosphonates"

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    • Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics 

      Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Kankanamalage, Anushka C. Galasiti; Uy, Roxanne Adeline Z.; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2013-11)
      The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme ...