Browsing Fairmount College of Liberal Arts and Sciences by Subject "Pancreatic Elastase/metabolism"

Now showing items 1-3 of 3

Dual function inhibitors of relevance to chronic obstructive pulmonary disease

Dou, Dengfeng; He, Guijia; Alliston, Kevin R.; Groutas, William C. (Elsevier, 2011-05-15)

The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are ...
Inhibition of human leukocyte elastase by derivatives of N-hydroxysuccinimide. A structure-activity-relationship study

Groutas, William C.; Brubaker, Michael J.; Stanga, Michael A.; Castrisos, J.C.; Crowley, J.P.; Schatz, E. J. (American Chemical Society, 1989-07-01)

A series of compounds derived from 3-alkyl-N-hydroxysuccinimide have been synthesized and their inhibitory activity toward human leukocyte elastase has been investigated. Compounds having an isobutyl or isopropyl group at ...
Inhibition of human leukocyte elastase by phosphate esters of N-hydroxysuccinimide and its derivatives: direct observation of a phosphorylated enzyme by 31P nuclear magnetic resonance spectroscopy

Groutas, William C.; Venkataraman, Radhika; Brubaker, Michael J.; Stanga, Michael A. (American Chemical Society, 1991-04-30)

A series of phosphate esters derived from N-hydroxysuccinimide and 3-alkyl-N-hydroxysuccinimide have been synthesized and found to be potent time-dependent irreversible inhibitors of human leukocyte elastase (HLE). The ...