Browsing Fairmount College of Liberal Arts and Sciences by Subject "Data quality"
Now showing items 1-5 of 5
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19F nuclear magnetic resonance and crystallographic studies of 5-fluorotryptophan-labeled anthrax protective antigen and effects of the receptor on stability
(American Chemical Society, 2014-02-04)The anthrax protective antigen (PA) is an 83 kDa protein that is one of three protein components of the anthrax toxin, an AB toxin secreted by Bacillus anthracis. PA is capable of undergoing several structural changes, ... -
Is procrastination related to low-quality data?
(Blackwell Publishing Ltd, 2020-07-03)While it is easy to assume that university students who wait until the last minute to complete surveys for their class research requirements provide low-quality data, this issue has not been empirically examined. The goal ... -
Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease
(American Chemical Society, 2016-03-10)Human noroviruses are the primary causative agents of acute gastroenteritis and a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or ... -
Structure-guided design and optimization of dipeptidyl inhibitors of Norovirus 3CL protease. Structure-activity relationships and biochemical, x-ray crystallographic, cell-based, and in vivo studies
(American Chemical Society, 2015-04-09)Norovirus infection constitutes the primary cause of acute viral gastroenteritis. There are currently no vaccines or norovirus-specific antiviral therapeutics available for the management of norovirus infection. Norovirus ... -
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease
(Elsevier, 2018-01-01)Acute nonbacterial gastroenteritis caused by noroviruses constitutes a global public health concern and a significant economic burden. There are currently no small molecule therapeutics or vaccines for the treatment of ...