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dc.contributor.authorMandadapu, Sivakoteswara Rao
dc.contributor.authorWeerawarna, Pathum M.
dc.contributor.authorPrior, Allan M.
dc.contributor.authorUy, Roxanne Adeline Z.
dc.contributor.authorAravapalli, Sridhar
dc.contributor.authorAlliston, Kevin R.
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorKim, Yunjeong
dc.contributor.authorHua, Duy H.
dc.contributor.authorChang, Kyeong-Ok
dc.contributor.authorGroutas, William C.
dc.date.accessioned2013-05-29T21:34:15Z
dc.date.available2013-05-29T21:34:15Z
dc.date.issued2013-05-16
dc.identifier.citationSivakoteswara Rao Mandadapu,Pathum M. Weerawarna,Allan M. Prior, Roxanne Adeline Z. Uy,Sridhar Aravapalli,Kevin R. Alliston,Gerald H. Lushington,Yunjeong Kim,Duy H. Hua,Kyeong-Ok Chang,William C. Groutas. 2013. Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus. -- Bioorganic & Medicinal Chemistry Letters, available May 16, 2013. ISSN 0960-894X, 10.1016/j.bmcl.2013.05.021en_US
dc.identifier.issn0960-894X
dc.identifier.urihttp://dx.doi.org/10.1016/j.bmcl.2013.05.021
dc.identifier.urihttp://hdl.handle.net/10057/5690
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractThe design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective concentration) of the macrocyclic inhibitor toward enterovirus 3C protease (CVB3 Nancy strain), and coronavirus (SARS-CoV) and norovirus 3C-like proteases, was determined to be 1.8, 15.5 and 5.1 μM, respectively.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & Medicinal Chemistry Letters;
dc.subjectMacrocyclic inhibitoren_US
dc.subjectProteasesen_US
dc.subjectPicornavirusen_US
dc.subjectNorovirusen_US
dc.subjectCoronavirusen_US
dc.titleMacrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirusen_US
dc.typeArticleen_US


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