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dc.contributor.authorMatalon, R.
dc.contributor.authorSurendran, S.
dc.contributor.authorMcDonald, J. David
dc.contributor.authorOkorodudu, A. O.
dc.contributor.authorTyring, S. K.
dc.contributor.authorMichals-Matalon, K.
dc.contributor.authorHarris, P.
dc.date.accessioned2013-04-22T17:52:57Z
dc.date.available2013-04-22T17:52:57Z
dc.date.issued2005
dc.identifier.citationMatalon, R.; Surendran, S.; McDonald, J. David; Okorodudu, A. O.; Tyring, S. K.; Michals-Matalon, K.; Harris, P. 2005. Abnormal expression of genes associated with development and inflammation in the heart of mouse maternal phenylketonuria offspring. International Journal of Immunopathology and Pharmacology, v.18 no.3 pp.557-65en_US
dc.identifier.otherPMID: 16164837
dc.identifier.urihttp://hdl.handle.net/10057/5645
dc.descriptionClick on the link to access the article (may not be free).en_US
dc.description.abstractThis study describes gene expression in the fetus hearts obtained from mouse model for phenylketonuria. These hearts have cardiovascular disease (CVD). Therefore genes involved in CVD were examined. Several genes associated with heart development and inflammation were found to be altered. In order to investigate whether the abnormal gene expression alters transcription and translation, the levels of troponin mRNA and protein were determined. One step real time RT-PCR showed a reduction in cardiac troponin I, troponin T2 and ryanodine receptor 2. Determination of troponin I and T protein levels showed reduced levels of these proteins. Our results suggest that altered gene expression affects protein production. These changes are likely involved in the cardiovascular defects seen in the mouse.en_US
dc.language.isoen_USen_US
dc.publisherPubMeden_US
dc.relation.ispartofseriesInternational Journal of Immunopathology and Pharmacology;v.18 no.3
dc.titleAbnormal expression of genes associated with development and inflammation in the heart of mouse maternal phenylketonuria offspringen_US
dc.typeArticleen_US


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