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dc.contributor.authorErcal, N.
dc.contributor.authorAykin-Burns, N.
dc.contributor.authorGurer-Orhan, H.
dc.contributor.authorMcDonald, J. David
dc.date.accessioned2013-04-18T14:19:02Z
dc.date.available2013-04-18T14:19:02Z
dc.date.issued2002-05
dc.identifier.citationErcal, N.; Aykin-Burns, N.; Gurer-Orhan, H.; McDonald, J. David. 2002. Oxidative stress in phenylketonuria animal model. Free Radical Biology and Medicine, v.32 no.9 pp.906-911en_US
dc.identifier.otherPMID: 11978492
dc.identifier.urihttp://dx.doi.org/10.1016/S0891-5849(02)00781-5
dc.identifier.urihttp://hdl.handle.net/10057/5633
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractOxidative stress is seen in various metabolic disorders for unknown reasons. Oxidative stress is defined as an imbalance between pro-oxidant and antioxidant status in favor of the former. This study investigated whether oxidative stress exists in phenylketonuria (PKU) using the BTBR-Pah(enu2) animal model for PKU. Animals (14-24 weeks old) were sacrificed and brain and red blood cells (RBCs) were obtained aseptically. The lipid peroxidation by-product, evaluated as malondialdehyde (MDA), was significantly higher in the brains and RBCs of PKU animals (n = 6) than in controls (n = 6). Glutathione/glutathione disulfide, a good indicator for tissue thiol status, was significantly decreased both in the brains and RBCs. Some antioxidant enzymes were also analyzed in RBCs, including glucose-6-phosphate dehydrogenase (G6PD), which provides the RBC's main reducing power, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and catalase detoxifies H2O2 by catalyzing its reduction to O2 and H2O. Both catalase and G6PD were significantly increased in the RBCs of PKU animals.en_US
dc.language.isoen_USen_US
dc.publisherPubMeden_US
dc.relation.ispartofseriesFree Radical Biology and Medicine;v.32 no.9
dc.titleOxidative stress in phenylketonuria animal modelen_US
dc.typeArticleen_US


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