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dc.contributor.authorUlloa-Aguirre, Alfredo
dc.contributor.authorDias, James A.
dc.contributor.authorBousfield, George R.
dc.contributor.authorHuhtaniemi, Ilpo
dc.contributor.authorReiter, Eric
dc.date.accessioned2013-03-11T19:55:28Z
dc.date.available2013-03-11T19:55:28Z
dc.date.issued2013
dc.identifier.citationUlloa-Aguirre, Alfredo; Dias, James A.; Bousfield, George; Huhtaniemi, Ilpo; Reiter, Eric. 2013. Trafficking of the Follitropin Receptor. Methods in Enzymology, v.521 pp.17-45en_US
dc.identifier.isbn9780123918628
dc.identifier.issn0076-6879
dc.identifier.urihttp://dx.doi.org/10.1016/B978-0-12-391862-8.00002-8
dc.identifier.urihttp://hdl.handle.net/10057/5556
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractThe follitropin or follicle-stimulating hormone receptor (FSHR) belongs to a highly conserved subfamily of the G protein-coupled receptor (GPCR) superfamily and is mainly expressed in specific cells in the gonads. As any other GPCR, the newly synthesized FSHR has to be correctly folded and processed in order to traffic to the cell surface plasma membrane and interact with its cognate ligand. In this chapter, we describe in detail the conditions and procedures used to study outward trafficking of the FSHR from the endoplasmic reticulum to the plasma membrane. We also describe some methods to analyze phosphorylation, β-arrestin recruitment, internalization, and recycling of this particular receptor, which have proved useful in our hands for dissecting its downward trafficking and fate following agonist stimulation.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesMethods in Enzymology;v.521
dc.subjectFollitropinen_US
dc.subjectFollitropin receptoren_US
dc.subjectFollicle-stimulating hormoneen_US
dc.subjectExpressionen_US
dc.subjectIntracellular traffickingen_US
dc.subjectDimerizationen_US
dc.subjectInternalizationen_US
dc.subjectRecyclingen_US
dc.titleTrafficking of the follitropin receptoren_US
dc.typeBook chapteren_US
dc.description.versionpeer reviewed
dc.rights.holderCopyright © 2013, Elsevier


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