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dc.contributor.authorMisak, Heath Edward
dc.contributor.authorZacharias, Nora M.
dc.contributor.authorSong, Zheng
dc.contributor.authorHwang, S.
dc.contributor.authorMan, Ka-Poh
dc.contributor.authorAsmatulu, Ramazan
dc.contributor.authorYang, Shang-You
dc.date.accessioned2013-03-05T18:46:54Z
dc.date.available2013-03-05T18:46:54Z
dc.date.issued2013-03
dc.identifier.citationMisak, Heath Edward; Zacharias, N.; Song, Z.; Hwang, S.; Man, K.-P.; Asmatulu, Ramazan; Yang, Shang-You. 2013. Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model, Journal of Biotechnology, v.164 no.1 pp.130-136en_US
dc.identifier.issn0168-1656
dc.identifier.urihttp://dx.doi.org/10.1016/j.jbiotec.2013.01.003
dc.identifier.urihttp://hdl.handle.net/10057/5550
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractAlbumin/drug loaded magnetic nanocomposite spheres were fabricated using an oil-in-oil emulsion/solvent evaporation method, and tested on a mouse model (experimental squamous cell carcinoma) to determine the efficacy of the drug delivery system (DDS) on skin cancer. This novel DDS consists of human serum albumin, poly(lactic-co-glycolic acid) (PLGA), 5-fluorouracil (5-Fu), magnetic nanoparticles (10 nm) and fluorescent labeling molecule (diphenylhexatriene). One of the major purposes of using albumin is that it likely provides internal binding to and retention by the inflammatory tissues to reduce the amount of magnetic nanoparticles needed in the drug loaded microspheres (750–1100 nm). This study is aimed at reducing many negative side effects of conventionally used chemotherapy drugs by localizing the chemotherapy drug, controlling the release of the therapeutic agent and encouraging uptake of the DDS into cancerous cells. A group of mice treated with (1) the magnetic targeted DDS were compared to the other three groups, including, (2) DDS without a magnet, (3) 5-Fu local injection, and (4) untreated groups. The fluorescent tracer was ubiquitously identified inside the tumor tissue, and the DDS/tumor tissue boundary presented a leaky interface. The test results clearly showed that the magnetic targeted DDS exhibited significantly superior therapeutic effects in treating the skin cancer, with the increased efficacy to halt the tumor growth.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesJournal of Biotechnology;v.164 no.1
dc.subjectSkin canceren_US
dc.subjectMagnetic target drug deliveryen_US
dc.subjectPolymeric delivery systemen_US
dc.subjectIn vivo testingen_US
dc.titleSkin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse modelen_US
dc.typeArticleen_US


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