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    Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model

    Date
    2013-03
    Author
    Misak, Heath Edward
    Zacharias, Nora M.
    Song, Zheng
    Hwang, S.
    Man, Ka-Poh
    Asmatulu, Ramazan
    Yang, Shang-You
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    Citation
    Misak, Heath Edward; Zacharias, N.; Song, Z.; Hwang, S.; Man, K.-P.; Asmatulu, Ramazan; Yang, Shang-You. 2013. Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model, Journal of Biotechnology, v.164 no.1 pp.130-136
    Abstract
    Albumin/drug loaded magnetic nanocomposite spheres were fabricated using an oil-in-oil emulsion/solvent evaporation method, and tested on a mouse model (experimental squamous cell carcinoma) to determine the efficacy of the drug delivery system (DDS) on skin cancer. This novel DDS consists of human serum albumin, poly(lactic-co-glycolic acid) (PLGA), 5-fluorouracil (5-Fu), magnetic nanoparticles (10 nm) and fluorescent labeling molecule (diphenylhexatriene). One of the major purposes of using albumin is that it likely provides internal binding to and retention by the inflammatory tissues to reduce the amount of magnetic nanoparticles needed in the drug loaded microspheres (750–1100 nm). This study is aimed at reducing many negative side effects of conventionally used chemotherapy drugs by localizing the chemotherapy drug, controlling the release of the therapeutic agent and encouraging uptake of the DDS into cancerous cells. A group of mice treated with (1) the magnetic targeted DDS were compared to the other three groups, including, (2) DDS without a magnet, (3) 5-Fu local injection, and (4) untreated groups. The fluorescent tracer was ubiquitously identified inside the tumor tissue, and the DDS/tumor tissue boundary presented a leaky interface. The test results clearly showed that the magnetic targeted DDS exhibited significantly superior therapeutic effects in treating the skin cancer, with the increased efficacy to halt the tumor growth.
    Description
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    URI
    http://dx.doi.org/10.1016/j.jbiotec.2013.01.003
    http://hdl.handle.net/10057/5550
    Collections
    • BIO Faculty Publications [271]
    • ISME Research Publications [207]

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