• Login
    View Item 
    •   Shocker Open Access Repository Home
    • Graduate Student Research
    • The Capitol Graduate Research Summit in Topeka
    • 2009 WSU Annual CGRS Abstracts
    • View Item
    •   Shocker Open Access Repository Home
    • Graduate Student Research
    • The Capitol Graduate Research Summit in Topeka
    • 2009 WSU Annual CGRS Abstracts
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Testing a global screening method to probe the role of epigenetics in an experimental model of estrogen-dependent uterine

    View/Open
    Megan_Simpson_CGRS_6_2009.pdf (19.44Kb)
    Date
    2009-03-12
    Author
    Simpson, Megan Odetta
    Hendry, William J. III
    Metadata
    Show full item record
    Abstract
    Diethylstilbestrol (DES), a synthetic estrogen, was widely administered to pregnant women between 1947 and 1971 based on the misconception that it could prevent miscarriages. Consequently, at least four million women and their fetuses were exposed to the drug and the offspring often developed various reproductive tract abnormalities, including cancer. We focused this study on DES-induced abnormalities in the uterus. More specifically, we screened for altered DNA methylation patterns. DNA methylation is a major component of the currently high-profile topic of epigenetics. Epigenetic modifications are now viewed as just as important to the development of cancer as are DNA mutations. We use Syrian golden hamsters to study the consequences of early developmental DES exposure. This study used Methylation Sensitive Restriction Fingerprinting (MSRF) to screen for altered DNA methylation patterns in uteri from control vs. neonatally DES-treated hamsters. Preliminary results show differential DNA methylation patterns in uteri of control vs. DES-treated hamsters. Further studies will be done to determine the identity and functional significance of the differentially methylated DNA elements.
    Description
    The project completed at the Wichita State University Department of Biological Sciences. Presented at the 6th Annual Capitol Graduate Research Summit, Topeka, KS, 2009
    URI
    http://hdl.handle.net/10057/5461
    Collections
    • 2009 WSU Annual CGRS Abstracts

    Browse

    All of Shocker Open Access RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Type

    My Account

    LoginRegister

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    DSpace software copyright © 2002-2021  DuraSpace
    Contact Us | Send Feedback
    DSpace Express is a service operated by 
    Atmire NV